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Zebrafish Antibodies

History of Zebrafish Research

Since George Streisinger pioneered his research using Zebrafish (Danio rerio) at the University of Oregon in 1972, Zebrafish have become a popular animal model. As a vertebrate model organism amenable to scalable screens, the Zebrafish has long been touted as having the potential to deliver new drug candidates. In the past few years, drug candidates discovered in Zebrafish have finally begun to reach human trials, suggesting that their potential may be turning into reality. Zebrafish is an ideal model organism for vertebrate development because it combines the best features of all the other models. Like the frog, zebrafish embryos develop externally and can be viewed and manipulated at all stages. However, the zebrafish embryo is more straightforward than the frog; it grows faster and is transparent like worms and fruit flies. Danio rerio is a suitable model to study embryology. Its small size, external fertilization, and fast development make it an ideal model species for vertebrate developmental biologists.

As vertebrates, they share a high degree of sequence and functional homology with mammals, including humans. Due to the conservation of cell biological and developmental processes across all vertebrates, studies in fish can give great insight into human disease processes. As mentioned, Zebrafish also provide researchers with a high degree of scalability and phenotypic richness. The ability to screen the whole organism grants scientists access to various complex phenotypes relative to disease. In a recent review, Swinney and Anthony found that approximately two-thirds of the first-in-class drug developed in the last decade was based on the phenotype-based method instead of the typical target-based approach (Nature Review Drug Discovery, 2011).

Featured Zebrafish Antibodies

Advantages of Using HUABIO Antibodies

Increased Reproducibility

Because recombinant antibody production involves sequencing the antibody light and heavy chains, recombinant antibody production allows researchers more control over the antigen. In contrast, hybridoma-based systems for producing monoclonal antibodies are subject to genetic drift and instability, increasing the potential for lot-to-lot variability. Since rAbs are defined by the sequences that encode them, they are more reliable and provide more reproducible results than mAbs. By adjusting experimental conditions, researchers can easily favor the isolation of antibodies against antigens.

Ease of Scalability and Continuous Supply

In vitro methods for producing antibodies are amenable to large-scale production, meaning antibody availability is unlikely to become a limiting factor. Recombinant antibodies can be produced in weeks as opposed to months. Moreover, since the recombinant antibody sequence is known, continuity of supply is assured. This means antibody expression can be carried out at any scale with guaranteed long-term supply giving you added peace of mind and continuity for projects of all sizes, making recombinant antibodies a great solution for long-term studies.

Animal-Free Tech

Once the antibody-producing genes are isolated, high-throughput in vitro manufacture can be implemented. This eliminates the numerous ethical and animal welfare concerns commonly associated with traditional monoclonal antibody production.

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