Epigenetics is defined as the study of phenotypic changes in organisms that are generally reversible without altering the DNA sequence. The organization of the chromatin can be modified by epigenetic mechanisms to create individual epigenetic landscapes for different cell types, resulting in unique properties and distribution patterns of gene expression.
Understanding epigenetic drivers of disease is critical in the detection and prevention of transcriptional abnormalities found in cancer as well as some neurological, inflammatory, and cardiovascular disorders. The ability to study epigenetic changes in cells and tissues could provide insights into causative mechanisms of disease and normal function and development.
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