YARS2 Rabbit Polyclonal Antibody (ER1902-50)

UNIPROT #

F1Q4R5

PROTEIN NAME

YARS2

SYNONYMS

CGI 04 antibody;FLJ13995 antibody;mitochondrial antibody;MLASA2 antibody;mt TyrRS antibody;SYYM_HUMAN antibody;Tyrosine tRNA ligase 2 mitochondrial antibody;Tyrosine tRNA ligase antibody;Tyrosine tRNA ligase mitochondrial antibody;Tyrosine--tRNA ligase antibody;Tyrosyl tRNA synthetase 2 mitochondrial antibody;Tyrosyl tRNA synthetase mitochondrial precursor antibody;Tyrosyl-tRNA synthetase antibody;TyrRS antibody;YARS 2 antibody;YARS2 antibody

SEQUENCE SIMILARITIES

Belongs to the class-I aminoacyl-tRNA synthetase family.

SUBCELLULAR LOCATION

Cytosol. Mitochondrion.

FUNCTION

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.