Rabbit polyclonal primary
YARS2 Rabbit Polyclonal Antibody (ER1902-50)
Recombinant protein within zebrafish yars2 aa 251-474 / 474.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
CGI 04 antibody; FLJ13995 antibody; mitochondrial antibody; MLASA2 antibody; mt TyrRS antibody; SYYM_HUMAN antibody; Tyrosine tRNA ligase 2 mitochondrial antibody; Tyrosine tRNA ligase antibody; Tyrosine tRNA ligase mitochondrial antibody; Tyrosine--tRNA ligase antibody; Tyrosyl tRNA synthetase 2 mitochondrial antibody; Tyrosyl tRNA synthetase mitochondrial precursor antibody; Tyrosyl-tRNA synthetase antibody; TyrRS antibody; YARS 2 antibody; YARS2 antibody
Belongs to the class-I aminoacyl-tRNA synthetase family.
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.