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Ferritin Recombinant Rabbit Monoclonal Antibody [SC0620] (ET1610-78)

Price: Regular price $385.00

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Catalog# ET1610-78

Rabbit Monoclonal to Ferritin

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Zebrafish

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Ferritin Recombinant Rabbit Monoclonal Antibody [SC0620] (ET1610-78)

Immunogen

Synthetic peptide within human fth1 aa 58-99 / 183.

Host

Rabbit

Positive Control

293T cell lysate, RAW264.7 cell lysate, Mouse liver tissue lysate, Mouse brain tissue lysate, Rat liver tissue lysate, Rat brain tissue lysate, SGC-7901, Jurkat, human spleen tissue, mouse liver tissue, rat liver tissue, rat spleen tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SC0620

RRID

AB_3069963

APPLICATION DILUTION

  • WB

  • 1:5,000-1:20,000

  • IF-Cell

  • 1:100

  • IF-Tissue

  • 1:200

  • IHC-P

  • 1:1,000

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 21 kDa

Isotype

IgG

TARGET

UNIPROT #

P02794

PROTEIN NAME

Ferritin

SYNONYMS

Cell proliferation-inducing gene 15 protein antibody;Ferritin H subunit antibody;Ferritin heavy chain antibody;Ferritin heavy polypeptide 1 antibody;Ferritin L subunit antibody;Ferritin, heavy polypeptide antibody;FRIH_HUMAN antibody;FTH antibody;FTH1 antibody;FTL antibody

SEQUENCE SIMILARITIES

Belongs to the ferritin family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and iron overload. Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. Aggregated ferritin transforms into a toxic form of iron called hemosiderin. Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal–protein interactions. Ferritin that is not combined with iron is called apoferritin.

CITATIONS

  • Jicheng Jiang,et al

    Nanovesicle-templated nanogel: A dual-modal platform integrating intracellular iron homeostasis disruption for ferroptosis and MRI-guided tumor diagnosis

  • Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone

  • Qing Tan,et al

    Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis

  • Yaxing Zhao,et al

    Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis

  • Ouyang, Z. Q., Shao, L. S., Wang, W. P., Ke, T. F., Chen, D., Zheng, G. R., Duan, X. R., Chu, J. X., Zhu, Y., Yang, L., Shan, H. Y., Huang, L., & Liao, C. D.

    Low intensity pulsed ultrasound ameliorates Adriamycin-induced chronic renal injury by inhibiting ferroptosis

  • Sun, H., Wang, D., Ren, J., Liu, J., Wang, Z., Wang, X., Zhang, A., Yang, K., Yang, M., & Zhou, H.

    Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway

  • Xia Yu,et al

    Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling

  • Chengwei Wu,et al

    NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer

  • Bao Jiaqi,et al

    Effects of the ferroptosis inducer erastin on osteogenic differentiation and biological pathways of primary osteoblasts

  • Yang Mengyuan,et al

    Cucurbitacin B induces ferroptosis in oral leukoplakia via the SLC7A11/mitochondrial oxidative stress pathway

  • Zhong, C., Yang, J., Zhang, Y., Fan, X., Fan, Y., Hua, N., Li, D., Jin, S., Li, Y., Chen, P., Chen, Y., Cai, X., Zhang, Y., Jiang, L., Yang, W., Yu, P., & Lin, H.

    TRPM2 Mediates Hepatic Ischemia-Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

  • Yang Shun,et al

    Mdivi-1 alleviates ferroptosis induced by hypoxia combined with propofol in HT22 cells by inhibiting excessive mitophagy

  • Ruiqin Hu,et al

    bmp10 maintains cardiac function by regulating iron homeostasis

  • Yingfei Chen,et al

    Resveratrol inhibits ferroptosis in the lung tissues of heat stroke-induced rats via the Nrf2 pathway

  • Ling Liu,et al

    Ferritinophagy-Mediated Hippocampus Ferroptosis is Involved in Cognitive Impairment in Immature Rats Induced by Hypoxia Combined with Propofol

  • Shuze Chen,et al

    Periodontal pathogen Fusobacterium nucleatum promotes ulcerative colitis by ferroptosis-mediated gut barrier disruption

  • Hu, R., Li, G., Xu, Q., & Chen, L.

    Iron supplementation inhibits hypoxia-induced mitochondrial damage and protects zebrafish liver cells from death

  • Identifying Ferroptosis‐Related Genes Associated with Weight Loss Outcomes and Regulation of Adipocyte Microenvironment

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