ZO2 Rabbit Polyclonal Antibody (R1402-2)

UNIPROT #

Q9UDY2

PROTEIN NAME

ZO2

SYNONYMS

C9DUPq21.11 antibody;DFNA51 antibody;DUP9q21.11 antibody;Friedreich ataxia region gene X104 (tight junction protein ZO-2) antibody;MGC26306 antibody;PFIC4 antibody;Tight junction protein 2 antibody;Tight junction protein ZO 2 antibody;Tight junction protein ZO-2 antibody;TJP2 antibody;X104 antibody;ZO 2 antibody;ZO-2 antibody;ZO2 antibody;ZO2_HUMAN antibody;Zona occludens 2 antibody;Zona occludens protein 2 antibody;Zonula occludens protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the MAGUK family.

TISSUE SPECIFICITY

This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton. ZO-1 and -2 are required for tight junction formation and function. In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators.