PRODUCT CODE: ER1706-33

ZIP12 Rabbit Polyclonal Antibody (ER1706-33)

Applications

  • WB

  • ICC

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

Western blot analysis of ZIP12 on HepG2 cell and rat lung tissue lysates using anti-ZIP12 antibody at 1/500 dilution.
  • Western blot analysis of ZIP12 on HepG2 cell and rat lung tissue lysates using anti-ZIP12 antibody at 1/500 dilution.
  • ICC staining ZIP12 in N2A cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
  • ICC staining ZIP12 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
  • Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-ZIP12 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-ZIP12 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse eyeball tissue using anti-ZIP12 antibody. Counter stained with hematoxylin.
Western blot analysis of ZIP12 on HepG2 cell and rat lung tissue lysates using anti-ZIP12 antibody at 1/500 dilution.

Applications

  • WB

  • ICC

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

ZIP12 Rabbit Polyclonal Antibody (ER1706-33)

Immunogen

Synthetic peptide within human zip12 aa 685-691 / 691 (extracellular).

Host

Rabbit

Positive Control

HepG2, N2A, SH-SY5Y, rat lung tissue, mouse liver tissue, mouse brain tissue, mouse eyeball tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Peptide affinity purified

MOLECULAR WEIGHT

70 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • ICC

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

ZIP12

SYNONYMS

bA570F3.1 antibody; FLJ30499 antibody; LIV 1 subfamily of ZIP zinc transporter 8 antibody; LIV-1 subfamily of ZIP zinc transporter 8 antibody; LZT Hs8 antibody; LZT-Hs8 antibody; LZTHs8 antibody; MGC43205 antibody; MGC51099 antibody; S39AC_HUMAN antibody; SLC39A12 antibody; Solute carrier family 39 (metal ion transporter) member 12 antibody; Solute carrier family 39 (zinc transporter) member 12 antibody; Solute carrier family 39 member 12 antibody; Zinc transporter ZIP12 antibody; ZIP 12 antibody; ZIP-12 antibody; ZIP12 antibody; Zrt and Irt like protein 12 antibody; Zrt- and Irt-like protein 12 antibody

SEQUENCE SIMILARITIES

Belongs to the ZIP transporter (TC 2.A.5) family.

TISSUE SPECIFICITY

Expressed in brain and eye.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. On the basis of sequence homology, the human SLC39A12 gene has been included as a member of a family of zinc (Zn) transporters designated as the ZRT-IRT-like proteins (current designation SLC39). ZRT-IRT-like proteins act in concert with another family of transporters, known in non-mammalian organisms as cation diffusion facilitators and in mammals as zinc transporters (ZnT), to regulate the distribution of Zn in the extra- versus intracellular milieu and within cellular compartments. Hence the ZnT maintain Zn homeostasis that is critical for the normal functioning of tissues including the CNS.