Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
ZHX2 Rabbit Polyclonal Antibody (ER1901-64)
Immunogen
Recombinant protein within human zhx2 aa 538-733 / 837.
Host
Rabbit
Positive Control
Daudi cell lysates, human esophagus tissue, mouse kidney tissue, Siha.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified.
MOLECULAR WEIGHT
92 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB:1:500-1:2,000
-
IHC-P:1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
ZHX2
SYNONYMS
AFP regulator 1 antibody; AFR1 antibody; Alpha fetoprotein regulator 1 antibody; Alpha-fetoprotein regulator 1 antibody; KIAA0854 antibody; RAF antibody; Regulator of AFP antibody; Transcription factor ZHX2 antibody; ZHX2 antibody; ZHX2_HUMAN antibody; Zinc finger and homeodomain protein 2 antibody; Zinc fingers and homeoboxes 2 antibody; Zinc fingers and homeoboxes protein 2 antibody
SEQUENCE SIMILARITIES
Belongs to the ZHX family.
TISSUE SPECIFICITY
Ubiquitously expressed. Expressed in podocytes.
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene. The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).