ZHX2 Rabbit Polyclonal Antibody (ER1901-64)

UNIPROT #

Q9Y6X8

PROTEIN NAME

ZHX2

SYNONYMS

AFP regulator 1 antibody;AFR1 antibody;Alpha fetoprotein regulator 1 antibody;Alpha-fetoprotein regulator 1 antibody;KIAA0854 antibody;RAF antibody;Regulator of AFP antibody;Transcription factor ZHX2 antibody;ZHX2 antibody;ZHX2_HUMAN antibody;Zinc finger and homeodomain protein 2 antibody;Zinc fingers and homeoboxes 2 antibody;Zinc fingers and homeoboxes protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the ZHX family.

TISSUE SPECIFICITY

Ubiquitously expressed. Expressed in podocytes.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene. The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).