UNIPROT #

Q96MM3

PROTEIN NAME

ZFP-42/REX-1

SYNONYMS

hREX-1 antibody; Reduced Expression 1 Protein antibody; Reduced expression protein 1 antibody; Rex-1 antibody; REX1 antibody; REX1 transcription factor antibody; Zfp-42 antibody; Zfp42 antibody; ZFP42 zinc finger protein antibody; ZFP42_HUMAN antibody; Zinc finger protein 42 homolog antibody; Zinc finger protein 754 antibody; ZNF754 antibody

SEQUENCE SIMILARITIES

Belongs to the krueppel C2H2-type zinc-finger protein family.

TISSUE SPECIFICITY

Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated by RNF12, leading to proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

REX-1/Zfp-42 was initially described as a factor present at high levels in murine F9 teratocarcinoma stem cells (EC).The Rex-1 (Zfp-42) gene encodes a zinc finger family transcription factor which is highly expressed in mouse and human embryonic stem cells. It is one of several gene markers used to identify human stem cells. REX-1 is found in spermatocytes and primary oocytes during replication and may play a role in meiosis. Recently, the expression of REX-1 in normal epithelial tissue cells has been demonstrated.