ZEB1 Recombinant Rabbit Monoclonal Antibody [JE57-64] (HA721318)

UNIPROT #

P37275

PROTEIN NAME

ZEB1

SYNONYMS

AREB 6 antibody;AREB6 antibody;BZP antibody;Delta crystallin enhancer binding factor 1 antibody;DELTA EF1 antibody;FECD6 antibody;MGC133261 antibody;Negative regulator of IL 2 antibody;Negative regulator of IL2 antibody;NIL 2 A antibody;NIL 2 A zinc finger protein antibody;NIL 2A antibody;NIL-2-A zinc finger protein antibody;NIL2A antibody;Posterior polymorphous corneal dystrophy 3 antibody;PPCD3 antibody;Represses interleukin 2 expression antibody;TCF 8 antibody;TCF-8 antibody;TCF8 antibody;Transcription factor 8 (represses interleukin 2 expression) antibody;Transcription factor 8 antibody;ZEB 1 antibody;ZEB antibody;ZEB1 antibody;ZEB1_HUMAN antibody;ZFHEP antibody;ZFHX 1A antibody;ZFHX1A antibody;Zinc finger E box binding homeobox 1 antibody;Zinc finger E-box-binding homeobox 1 antibody;Zinc finger homeodomain enhancer binding protein antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain is shown on the right. Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas A recent study suggested its contributing role in lung cancer invasiveness and metastasis development. Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.