Western blot analysis of ZAC on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ER1901-48, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
Lane 1: human kidney tissue lysate
Lane 2: HepG2 cell lysate
Rabbit polyclonal primary
ZAC Rabbit Polyclonal Antibody (ER1901-48)
Synthetic peptide within human zac aa 139-188 / 412.
Human kidney tissue lysate, HepG2 cell lysate, N2A, SiHa, rat brain tissue, human liver tissue, human kidney tissue, mouse cerebellum tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Zinc-activated ligand-gated ion channel;Ligand-gated ion channel zinc-activated 1;Ligand-gated ion-channel receptor L2;L2;LGICZ;LGICZ1;ZAC
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.
Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes. ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.