ZAC Rabbit Polyclonal Antibody (ER1901-48)

UNIPROT #

Q401N2

PROTEIN NAME

ZAC

SYNONYMS

Zinc-activated ligand-gated ion channel;Ligand-gated ion channel zinc-activated 1;Ligand-gated ion-channel receptor L2;L2;LGICZ;LGICZ1;ZAC

SEQUENCE SIMILARITIES

Belongs to the ligand-gated ion channel (TC 1.A.9) family.

TISSUE SPECIFICITY

Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes. ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach. The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.