YTHDF2 Rabbit Polyclonal Antibody (HA500351)

UNIPROT #

Q9Y5A9

PROTEIN NAME

YTHDF2

SYNONYMS

9430020E02Rik antibody;CAHL antibody;CLL associated antigen KW 14 antibody;CLL-associated antigen KW-14 antibody;HGRG8 antibody;High glucose regulated protein 8 antibody;High-glucose-regulated protein 8 antibody;NY REN 2 antibody;Renal carcinoma antigen NY REN 2 antibody;Renal carcinoma antigen NY-REN-2 antibody;YTH domain family 2 antibody;YTH domain family member 2 antibody;YTH domain family protein 2 antibody;YTH N6 methyladenosine RNA binding protein 2 antibody;YTHD2_HUMAN antibody;YTHDF 2 antibody;YTHDF2 antibody

SUBCELLULAR LOCATION

Nucleus, cytosol.

FUNCTION

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex. Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs. Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development. Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases. Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation. Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets.