YKL-40 / CHI3L1 Mouse Monoclonal Antibody [A3G10] (EM1902-31)

UNIPROT #

P36222

PROTEIN NAME

YKL-40/CHI3L1

SYNONYMS

39 kDa synovial protein antibody;ASRT7 antibody;Cartilage glycoprotein 39 antibody;CGP-39 antibody;CGP39 antibody;CH3L1_HUMAN antibody;CHI3L1 antibody;chitinase 3 like 1 (cartilage glycoprotein 39) antibody;chitinase 3 like 1 antibody;Chitinase 3 like protein 1 precursor antibody;chitinase antibody;Chitinase-3-like protein 1 antibody;Chondrocyte protein YKL40 antibody;GP 39 antibody;GP-39 antibody;GP39 antibody;HC gp39 antibody;HCGP 3P antibody;hCGP-39 antibody;HCgp39 antibody;YKL 40 antibody;YKL-40 antibody;YKL40 antibody;YYL 40 antibody

SEQUENCE SIMILARITIES

Belongs to the glycosyl hydrolase 18 family.

TISSUE SPECIFICITY

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Extracellular space, Endoplasmic reticulum, Cytoplasm.

FUNCTION

Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells, vascular smooth muscle cells, and hepatic stellate cells. The biological function of YKL-40 is unclear. It is not known to have a specific receptor. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas and asthma. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. YKL-40 lacks chitinase activity due to mutations within the active site.