XPD Recombinant Rabbit Monoclonal Antibody [JE55-02] (ET7110-93)

UNIPROT #

P18074

PROTEIN NAME

XPD

SYNONYMS

TFIIH 80 kDa subunit antibody;Basic transcription factor 2 80 kDa subunit antibody;BTF2 p80 antibody;COFS 2 antibody;COFS2 antibody;CXPD antibody;DNA excision repair protein ERCC 2 antibody;DNA excision repair protein ERCC-2 antibody;DNA repair protein complementing XP D cells antibody;DNA repair protein complementing XP-D cells antibody;EM9 antibody;ERCC 2 antibody;ERCC2 antibody;ERCC2_HUMAN antibody;Excision repair 2 antibody;Excision repair cross complementing rodent repair deficiency complementation antibody;Excision repair cross complementing rodent repair deficiency, complementation group 2 antibody;MAG antibody;MGC102762 antibody;MGC126218 antibody;MGC126219 antibody;OTTHUMP00000045860 antibody;OTTHUMP00000045861 antibody;OTTHUMP00000045862 antibody;OTTHUMP00000045863 antibody;TFIIH 80 kDa subunit antibody;TFIIH basal transcription factor complex 80 kDa subunit antibody;TFIIH Basal Transcription Factor Complex Helicase Subunit antibody;TFIIH basal transcription factor complex helicase XPD subunit antibody;TFIIH basal transcription factor complex p80 subunit antibody;TFIIH p80 antibody;TTD antibody;Xeroderma pigmentosum complementary group D antibody;Xeroderma pigmentosum group D complementing protein antibody;Xeroderma pigmentosum group D-complementing protein antibody;XPD antibody;XPDC antibody

SEQUENCE SIMILARITIES

Belongs to the helicase family. RAD3/XPD subfamily.

POST-TRANSLATIONAL MODIFICATION

ISGylated.

SUBCELLULAR LOCATION

Nucleus, spindle.

FUNCTION

ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.