XPA Rabbit Polyclonal Antibody (HA500133)
Catalog# HA500133
Rabbit Polyclonal to XPA
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WB
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: Hela cell lysate
Lane 2: A431 cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
XPA Rabbit Polyclonal Antibody (HA500133)
Immunogen
Synthetic peptide within human xpa aa 20-60.
Host
Rabbit
Positive Control
Hela cell lysate, A431 cell lysate, mouse colon tissue, human thyroid tissue, human colon carcinoma tissue, human prostate carcinoma tissue, human breast carcinoma tissue, human stomach carcinoma tissue, mouse testis tissue, mouse kidney tissue, rat large intestine tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:200-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 31 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
XPA
SYNONYMS
DNA repair protein complementing XP A cells antibody;DNA repair protein complementing XP-A cells antibody;DNA repair protein complementing XPA cells antibody;Excision repair controlling antibody;Xeroderma pigmentosum 1 antibody;Xeroderma pigmentosum complementation group A antibody;Xeroderma pigmentosum group A complementing protein antibody;Xeroderma pigmentosum group A-complementing protein antibody;XP 1 antibody;XP1 antibody;xpa antibody;XPA_HUMAN antibody;Xpac antibody
SUBCELLULAR LOCATION
Nucleus.
FUNCTION
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer.
CITATIONS
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Dou Renjie,et al
Oroxylin A inhibits UVB-induced non-melanoma skin cancer by regulating XPA degradation
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WB
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Human
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Citation
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