xCT / SLC7A11 Mouse Monoclonal Antibody [A7C6] (HA600098)
Catalog# HA600098
Mouse Monoclonal to xCT/SLC7A11
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Mouse
Lysates/proteins at 10 µg/Lane.
Predicted band size: 55 kDa
Observed band size: 55 kDa
Exposure time: 2 minute 30 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA600098) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1/50,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Mouse monoclonal primary
Product Name
xCT / SLC7A11 Mouse Monoclonal Antibody [A7C6] (HA600098)
Immunogen
293 cell line overexpressing slc7a11.
Host
Mouse
Positive Control
HT-29 cell lysates, HeLa, A549, HT-29, human colon tissue, human pancreas tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A7C6
RRID
APPLICATION DILUTION
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WB
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1:1,000
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IF-Cell
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1:100-1:250
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IHC-P
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1:200-1:600
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FC
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1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 55 kDa
Isotype
IgG1
TARGET
UNIPROT #
PROTEIN NAME
xCT/SLC7A11
SYNONYMS
Amino acid transport system xc xCT antibody antibody;Amino acid transport system xc- antibody;Calcium channel blocker resistance protein CCBR1 antibody;Calcium channel blocker resistance protein CCBR1 antibody antibody;CCBR1 antibody;Cysteine/glutamate transporter antibody antibody;Cystine/glutamate transporter antibody;OTTHUMP00000164578 antibody;SLC7A11 antibody;Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody;solute carrier family 7 antibody;Solute carrier family 7 member 11 antibody;Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody;SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody;xCT antibody;XCT_HUMAN antibody
SUBCELLULAR LOCATION
Cell membrane, Cell projection, microvillus membrane.
FUNCTION
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
CITATIONS
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Songyuan Yang,et al
The SIRT6/BAP1/xCT signaling axis mediates ferroptosis in cisplatin-induced AKI
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WB
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Human
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Citation
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H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells
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WB
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Mouse
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Citation
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-
Lan Kunmei,et al
Sensing of mitochondrial DNA by ZBP1 promotes RIPK3- mediated necroptosis and ferroptosis in response to diquat poisoning
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WB
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Mouse
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Citation
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-
He Yijing,et al
Polystyrene nanoplastic exposure actives ferroptosis by oxidative stress-induced lipid peroxidation in porcine oocytes during maturation
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WB
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Porcine
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Citation
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Chengwei Wu,et al
NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer
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WB
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Mouse
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Citation
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Zhou Xuyou,et al
Nicotine promotes Staphylococcus aureus-induced osteomyelitis by activating the Nrf2/Slc7a11 signaling axis
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IHC
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IF
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Citation
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Lu Feng,et al
QBT improved cognitive dysfunction in rats with vascular dementia by regulating the Nrf2/xCT/GPX4 and NLRP3/Caspase-1/GSDMD pathways to inhibit ferroptosis and pyroptosis of neurons
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WB
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Citation
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Ze Li,et al
Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway
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WB
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Rat
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Citation
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p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis
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WB
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Mouse
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Citation
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Bao J, Wang Z, Yang Y, et al
Interleukin-17 alleviates erastin-induced alveolar bone loss by suppressing ferroptosis via interaction between NRF2 and p-STAT3
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IHC
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Mouse
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Citation
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Wu Ziying,et al
Multimodal enhancement of ferroptosis for synergistic cascade colorectal cancer therapy
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WB
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Mouse
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Citation
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Congcong Lu,et al
Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
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IHC
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Mouse
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Citation
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Di Yuqin,et al
MAPK Signaling-Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin-Induced Apoptosis and Ferroptosis
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IHC
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Human
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Citation
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Chen, Y. M., Xu, W., Liu, Y., Zhang, J. H., Yang, Y. Y., Wang, Z. W., Sun, D. J., Li, H., Liu, B., & Chen, L. X.
Anomanolide C suppresses tumor progression and metastasis by ubiquitinating GPX4-driven autophagy-dependent ferroptosis in triple negative breast cancer
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WB
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Mouse
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Citation
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Li L, Ye Z, Xia Y, et al
YAP/ACSL4 Pathway-Mediated Ferroptosis Promotes Renal Fibrosis in the Presence of Kidney Stones
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WB
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Mouse
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Citation
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