WSX-1 Rabbit Polyclonal Antibody (HA500324)

UNIPROT #

Q6UWB1

PROTEIN NAME

WSX-1

SYNONYMS

Class I cytokine receptor antibody;CRL1 antibody;Cytokine receptor-like 1 antibody;I27RA_HUMAN antibody;IL-27 receptor subunit alpha antibody;IL-27R subunit alpha antibody;IL-27R-alpha antibody;IL-27RA antibody;IL27R alpha antibody;IL27R antibody;Il27ra antibody;Interleukin 27 receptor alpha chain precursor antibody;Interleukin 27 receptor antibody;Interleukin-27 receptor subunit alpha antibody;Protein CRL1 antibody;T cell cytokine receptor type 1 antibody;TCCR antibody;Type 1 T cell cytokine receptor antibody;Type I T-cell cytokine receptor antibody;WSX-1 antibody;WSX1 antibody;ZcytoR1 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.