WAPL Recombinant Rabbit Monoclonal Antibody [JE51-75] (ET7110-25)

UNIPROT #

Q7Z5K2

PROTEIN NAME

WAPL

SYNONYMS

FOE antibody;Friend of EBNA2 (Epstein Barr virus nuclear protein 2) antibody;Friend of EBNA2 protein antibody;KIAA0261 antibody;OTTHUMP00000020004 antibody;WAPAL antibody;WAPL antibody;WAPL_HUMAN antibody;Wings apart like homolog antibody;Wings apart like homolog (Drosophila) antibody;Wings apart-like protein homolog antibody

SEQUENCE SIMILARITIES

Belongs to the WAPL family.

TISSUE SPECIFICITY

Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.

SUBCELLULAR LOCATION

Chromosome, Cytoplasm, Nucleus.

FUNCTION

WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie-Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.