VPS34 Recombinant Rabbit Monoclonal Antibody [PSH10-64] (HA723229)

UNIPROT #

Q8NEB9

PROTEIN NAME

VPS34

SYNONYMS

hVps34 antibody;MGC61518 antibody;Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody;Phosphatidylinositol 3 kinase class 3 antibody;Phosphatidylinositol 3 kinase p100 subunit antibody;Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody;Phosphatidylinositol 3-kinase p100 subunit antibody;Phosphoinositide 3 kinase class 3 antibody;Phosphoinositide-3-kinase class 3 antibody;PI3 kinase type 3 antibody;PI3-kinase type 3 antibody;PI3K type 3 antibody;Pik3c3 antibody;PK3C3_HUMAN antibody;PtdIns 3 kinase type 3 antibody;PtdIns-3-kinase type 3 antibody;Vps 34 antibody;Vps34 antibody

SUBCELLULAR LOCATION

Midbody, Late endosome, Cytoplasmic vesicle, autophagosome.

FUNCTION

Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. There is only one known class III PI 3-kinase, Vps34, which is also the only PI 3-kinase expressed in all eukaryotic cells. In humans it is encoded by the PIK3C3 gene. In human cells Vps34 associates with a regulatory subunit, PIK3R4(p150, Vps15). Vps34 was first identified in a Saccharomyces cerevisiae (budding yeast) screen for proteins involved vesicle-mediated vacuolar protein sorting (hence Vps). A number of proteins containing a phosphoinositide binding domain specific for PtdIns(3)P that function in cellular protein trafficking have been identified.