VMAT1 Rabbit Polyclonal Antibody (R1307-7)

UNIPROT #

P54219

PROTEIN NAME

VMAT1

SYNONYMS

4832416I10Rik antibody;Adrenal chromaffin granule amine transporter; CGAT antibody;CGAT antibody;Chromaffin granule amine transporter antibody;MGC28683 antibody;MGC37299 antibody;SLC18A1 antibody;Solute carrier family 18 (vesicular monoamine), member 1 antibody;Solute carrier family 18 member 1 antibody;VAT 1 antibody;VAT1 antibody;Vesicular amine transporter 1 antibody;VMAT 1 antibody;VMAT1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the major facilitator superfamily. Vesicular transporter family.

TISSUE SPECIFICITY

Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).

SUBCELLULAR LOCATION

Cytoplasmic vesicle membrane; Endoplasmic reticulum membrane

FUNCTION

Vesicular monoamine transporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a protein that in humans is encoded by the SLC18A1 gene. VMAT1 is an integral membrane protein, which is embedded in synaptic vesicles and serves to transfer monoamines, such as norepinephrine, epinephrine, dopamine, and serotonin, between the cytosol and synaptic vesicles. SLC18A1 is an isoform of the vesicular monoamine transporter.