VLDL Receptor Rabbit Polyclonal Antibody (HA500194)

UNIPROT #

P98155

PROTEIN NAME

VLDL Receptor

SYNONYMS

FLJ35024 antibody;Very low density lipoprotein receptor antibody;Very low-density lipoprotein receptor antibody;VLDL R antibody;VLDL receptor antibody;VLDL-R antibody;VLDLR antibody;VLDLR_HUMAN antibody;VLDLRCH antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, clathrin-coated pit.

FUNCTION

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.