PRODUCT CODE: 0812-4

Vitamin K-dependent protein S Rabbit Polyclonal Antibody (0812-4)

Applications

  • WB

REACTIVITY

  • Human

Western blot analysis on human serum using anti- Vitamin K-dependent protein S polyclonal antibody.
  • Western blot analysis on human serum using anti- Vitamin K-dependent protein S polyclonal antibody.
Western blot analysis on human serum using anti- Vitamin K-dependent protein S polyclonal antibody.

Applications

  • WB

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Vitamin K-dependent protein S Rabbit Polyclonal Antibody (0812-4)

Immunogen

Synthetic peptide within human vitamin k-dependent protein s aa 627-676 / 676.

Host

Rabbit

Positive Control

Human serum

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

70 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000

TARGET

UNIPROT #

PROTEIN NAME

Vitamin K-dependent protein S

SYNONYMS

Preproprotein S antibody; Propiece of latent protein S antibody; PROS 1 antibody; PROS antibody; PROS_HUMAN antibody; proS1 antibody; Protein S alpha antibody; Protein Sa antibody; PS 21 antibody; PS 22 antibody; PS 23 antibody; PS 24 antibody; PS 25 antibody; PS 26 antibody; PS21 antibody; PS22 antibody; PS23 antibody; PS24 antibody; PS25 antibody; PS26 antibody; PSA antibody; THPH5 antibody; THPH6 antibody; Vitamin K dependent protein S antibody; Vitamin K-dependent plasma protein S antibody; Vitamin K-dependent protein S antibody

TISSUE SPECIFICITY

Plasma.

POST-TRANSLATIONAL MODIFICATION

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

SUBCELLULAR LOCATION

Secretory protein

FUNCTION

Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Its major function is as a cofactor to facilitate the action of activated protein C (APC) on its substrates, activated factor V (FVa), and activated factor VIII (FVIIIa).