Vitamin K-dependent protein C Rabbit Polyclonal Antibody (0812-6)

UNIPROT #

P04070

PROTEIN NAME

Vitamin K-dependent protein C

SYNONYMS

Activation peptide antibody;Anticoagulant protein C antibody;APC antibody;Autoprothrombin IIA antibody;Blood coagulation factor XIV antibody;EC 3.4.21.69 antibody;PC antibody;proC antibody;PROC_HUMAN antibody;PROC1 antibody;Protein C (inactivator of coagulation factors Va and VIIIa) antibody;THPH3 antibody;THPH4 antibody;Vitamin K dependent protein C antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family.

TISSUE SPECIFICITY

Plasma; synthesized in the liver.

POST-TRANSLATIONAL MODIFICATION

The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.; N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.; May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.

SUBCELLULAR LOCATION

Secretory protein

FUNCTION

Protein C is a Vitamin K-dependent glycoprotein that is produced in the liver. Protein C is similar to the prothrombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and the proenzyme concentration is approximately 3?g/ml. Protein C regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Protein C deficiency is associated with inherited thrombophilia, ecchymotic skin lesions.