PRODUCT CODE: 0812-6

Vitamin K-dependent protein C Rabbit Polyclonal Antibody (0812-6)

Applications

  • WB

REACTIVITY

  • Human

Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.
  • Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.
Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.

Applications

  • WB

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Vitamin K-dependent protein C Rabbit Polyclonal Antibody (0812-6)

Immunogen

Peptide

Host

Rabbit

Positive Control

K562, human plasma

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

52/80 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000

TARGET

UNIPROT #

PROTEIN NAME

Vitamin K-dependent protein C

SYNONYMS

Activation peptide antibody; Anticoagulant protein C antibody; APC antibody; Autoprothrombin IIA antibody; Blood coagulation factor XIV antibody; EC 3.4.21.69 antibody; PC antibody; proC antibody; PROC_HUMAN antibody; PROC1 antibody; Protein C (inactivator of coagulation factors Va and VIIIa) antibody; THPH3 antibody; THPH4 antibody; Vitamin K dependent protein C antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S1 family.

TISSUE SPECIFICITY

Plasma; synthesized in the liver.

POST-TRANSLATIONAL MODIFICATION

The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.; N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.; May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.

SUBCELLULAR LOCATION

Secretory protein

FUNCTION

Protein C is a Vitamin K-dependent glycoprotein that is produced in the liver. Protein C is similar to the prothrombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and the proenzyme concentration is approximately 3?g/ml. Protein C regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Protein C deficiency is associated with inherited thrombophilia, ecchymotic skin lesions.