Rabbit polyclonal primary
Vitamin K-dependent protein C Rabbit Polyclonal Antibody (0812-6)
Synthetic peptide within human vitamin k-dependent protein c aa 412-461 / 461.
K562, human plasma
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified
Vitamin K-dependent protein C
Activation peptide antibody; Anticoagulant protein C antibody; APC antibody; Autoprothrombin IIA antibody; Blood coagulation factor XIV antibody; EC 220.127.116.11 antibody; PC antibody; proC antibody; PROC_HUMAN antibody; PROC1 antibody; Protein C (inactivator of coagulation factors Va and VIIIa) antibody; THPH3 antibody; THPH4 antibody; Vitamin K dependent protein C antibody
Belongs to the peptidase S1 family.
Plasma; synthesized in the liver.
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.; N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.; May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
Protein C is a Vitamin K-dependent glycoprotein that is produced in the liver. Protein C is similar to the prothrombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and the proenzyme concentration is approximately 3?g/ml. Protein C regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Protein C deficiency is associated with inherited thrombophilia, ecchymotic skin lesions.