Vitamin D Receptor Rabbit Polyclonal Antibody (ER1802-40)

UNIPROT #

P11473

PROTEIN NAME

Vitamin D Receptor

SYNONYMS

1 25 dihydroxyvitamin D3 receptor antibody;1 antibody;1,25 dihydroxyvitamin D3 receptor antibody;1,25-@dihydroxyvitamin D3 receptor antibody;25-dihydroxyvitamin D3 receptor antibody;Member 1 antibody;NR1I1 antibody;Nuclear receptor subfamily 1 group I member 1 antibody;PPP1R163 antibody;Protein phosphatase 1, regulatory subunit 163 antibody;VDR antibody;VDR_HUMAN antibody;Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody;Vitamin D hormone receptor antibody;Vitamin D nuclear receptor variant 1 antibody;Vitamin D receptor antibody;Vitamin D3 receptor antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR1 subfamily.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.