Vitamin D Binding protein Recombinant Rabbit Monoclonal Antibody [JM10-36] (ET1703-09)

UNIPROT #

P02774

PROTEIN NAME

Vitamin D Binding protein

SYNONYMS

DBP antibody;DBP/GC antibody;GC antibody;Gc globulin antibody;Gc-globulin antibody;GRD3 antibody;Group specific component antibody;Group specific component vitamin D binding protein antibody;Group-specific component antibody;hDBP antibody;VDB antibody;VDBG antibody;VDBP antibody;Vitamin D binding alpha globulin antibody;Vitamin D-binding protein antibody;VTDB_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ALB/AFP/VDB family.

TISSUE SPECIFICITY

Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.

POST-TRANSLATIONAL MODIFICATION

Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. Vitamin D-binding protein belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It is able to bind the various forms of vitamin D including ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), the 25-hydroxylated forms (calcifediol), and the active hormonal product, 1,25-dihydroxyvitamin D (calcitriol). The major proportion of vitamin D in blood is bound to this protein. It transports vitamin D metabolites between skin, liver and kidney, and then on to the various target tissues. As Gc protein-derived macrophage activating factor it is a Macrophage Activating Factor (MAF) that has been tested for use as a cancer treatment that would activate macrophages against cancer cells.