Recombinant Rabbit monoclonal primary
Vitamin D Binding protein Recombinant Rabbit Monoclonal Antibody [JM10-36] (ET1703-09)
SKOV-3, Hela, HepG2, human kidney tissue, human lung tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Vitamin D Binding protein
DBP antibody; DBP/GC antibody; GC antibody; Gc globulin antibody; Gc-globulin antibody; GRD3 antibody; Group specific component antibody; Group specific component vitamin D binding protein antibody; Group-specific component antibody; hDBP antibody; VDB antibody; VDBG antibody; VDBP antibody; Vitamin D binding alpha globulin antibody; Vitamin D-binding protein antibody; VTDB_HUMAN antibody
Belongs to the ALB/AFP/VDB family.
Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.
Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.
Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.