UNIPROT #

P49767

PROTEIN NAME

VEGFC

SYNONYMS

Flt 4L antibody; Flt4 ligand antibody; FLT4 ligand DHM antibody; Flt4-L antibody; Flt4L antibody; Vascular endothelial growth factor C antibody; Vascular endothelial growth factor related protein antibody; Vascular endothelial growth factor-related protein antibody; VEGF C antibody; VEGF-C antibody; Vegfc antibody; VEGFC_HUMAN antibody; VRP antibody

SEQUENCE SIMILARITIES

Belongs to the PDGF/VEGF growth factor family.

TISSUE SPECIFICITY

Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.

POST-TRANSLATIONAL MODIFICATION

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

SUBCELLULAR LOCATION

Secreted

FUNCTION

VEGF-A plays a paramount role in tumor angiogenesis, VEGF-C has been characterized as an essential lymphangiogenic factor that promotes cancer metastasis. VEGF-C is a ligand for both VEGF-R3 and VEGF-R2 but has a high affinity for VEGF-R3. It has been reported that the VEGF-C/VEGF-R3 axis is activated in subsets of leukemia patients.