VE Cadherin Recombinant Rabbit Monoclonal Antibody [PSH03-15] (HA721943)

UNIPROT #

P33151

PROTEIN NAME

VE Cadherin

SYNONYMS

7B 4 antibody;7B4 antibody;7B4 antigen antibody;CADH5_HUMAN antibody;Cadherin 5 antibody;Cadherin 5 type 2 antibody;Cadherin 5, type 2 (vascular endothelium) antibody;Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody;cadherin, vascular endothelial antibody;cadherin, vascular endothelial, 1 antibody;Cadherin-5 antibody;Cadherin5 antibody;CD 144 antibody;CD144 antibody;CD144 antigen antibody;CDH 5 antibody;CDH5 antibody;CDH5 protein antibody;Endothelial specific cadherin antibody;FLJ17376 antibody;OTTHUMP00000174777 antibody;Vascular endothelial cadherin antibody;Vascular epithelium cadherin antibody;VE Cad antibody;VE-cadherin antibody;VEC antibody

SUBCELLULAR LOCATION

Cell junction. Cell membrane.

FUNCTION

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development . The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton. While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking . Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers . Research studies indicate that cancer cells have upregulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis. Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers .