Vang-like protein 1 Rabbit Polyclonal Antibody (0905-5)

UNIPROT #

Q8TAA9

PROTEIN NAME

Vang-like protein 1

SYNONYMS

ANGL planar cell polarity protein 1 antibody;KAI1 C-terminal interacting tetraspanin antibody;KITENIN antibody;Loop tail protein 2 homolog antibody;Loop-tail protein 2 homolog antibody;LPP2 antibody;MGC5338 antibody;STB2 antibody;STBM2 antibody;Strabismus 2 antibody;Strabismus, Drosophila, homolog of, 2 antibody;Van Gogh like protein 1 antibody;Van Gogh, Drosophila, homolog of, 1 antibody;Van Gogh-like protein 1 antibody;Vang like 1 (van gogh, Drosophila) antibody;Vang like protein 1 antibody;Vang-like 1 antibody;Vang-like protein 1 antibody;VANG1_HUMAN antibody;VANGL 1 antibody;Vangl1 antibody

SEQUENCE SIMILARITIES

Belongs to the Vang family.

TISSUE SPECIFICITY

According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Vang-like protein 1 is a multi-pass membrane protein, expressed specifically in testis and ovary. It interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both downregulated in several cancer cell lines and primary tumors. Defects in VANGL1 are a cause of neural tube defects (NTD) and a cause of sacral defect with anterior meningocele (SDAM).