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UTF1 Rabbit Polyclonal Antibody (R1305-4)

Price: Regular price $315.00

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Catalog# R1305-4

Rabbit Polyclonal to UTF1

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

UTF1 Rabbit Polyclonal Antibody (R1305-4)

Immunogen

Synthetic peptide corresponding to human utf1 aa 41-90 / 341.

Host

Rabbit

Positive Control

Human brain, D3, human testis

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073214

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IHC-P

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 36 kDa

Isotype

IgG

TARGET

UNIPROT #

Q5T230

PROTEIN NAME

UTF1

SYNONYMS

hUTF 1 antibody;hUTF1 antibody;Undifferentiated embryonic cell transcription factor 1 antibody;UTF 1 antibody;UTF1 antibody;UTF1_HUMAN antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cell nucleus

FUNCTION

Undifferentiated embryonic cell transcription factor 1 (UTF1) is expressed in cells of the inner cell mass and the epiblast. Upon activation by Oct-3/4, UTF1 may be responsible for the rapid proliferation and tumorigenic properties of embryonic stem cells. Sox2 is also part of the Oct-3/4-containing complex able to bind the regulatory region of UTF1. UTF1 acts as a transcriptional coactivator of ATF2 and it binds to the N-terminal region of ATF2. Reduced expression in embryonic stem cells (ESCs) is associated with failure to differentiate properly, although self-renewal is unaffected.

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