USP29 Rabbit Polyclonal Antibody (ER1902-76)

UNIPROT #

Q9HBJ7

PROTEIN NAME

USP29

SYNONYMS

Deubiquitinating enzyme 29 antibody;HOM TES 84/86 antibody;MGC163266 antibody;MGC163270 antibody;Ubiquitin carboxyl terminal hydrolase 29 antibody;Ubiquitin carboxyl-terminal hydrolase 29 antibody;Ubiquitin specific peptidase 29 antibody;Ubiquitin specific processing protease 29 antibody;Ubiquitin specific processing protease antibody;Ubiquitin thiolesterase 29 antibody;Ubiquitin-specific-processing protease 29 antibody;UBP29_HUMAN antibody;USP 29 antibody;Usp29 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C19 family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The DNA damage checkpoint is essential for the maintenance of genome integrity after genotoxic stress, and also for cell survival in eukaryotes. Claspin has a key role in the ATR (ATM and Rad3-related)-Chk1 branch of the DNA damage checkpoint and is also required for correct DNA replication. To achieve properly these functions, Claspin is tightly regulated by ubiquitinin-dependent proteasomal degradation, which controls Claspin levels in a DNA-damage- and cell-cycle-dependent manner. USP29 is a regulator of Claspin, USP29 is a player in the ATR-Chk1 pathway and the control of DNA replication.