UNIPROT #

P54578

PROTEIN NAME

USP14

SYNONYMS

Deubiquitinating enzyme 14 antibody; TGT antibody; tRNA guanine transglycosylase 60 kD subunit antibody; tRNA guanine transglycosylase antibody; Ubiquitin carboxyl terminal hydrolase 14 antibody; Ubiquitin carboxyl-terminal hydrolase 14 antibody; Ubiquitin specific peptidase 14 antibody; Ubiquitin specific processing protease 14 antibody; Ubiquitin specific protease 14 antibody; Ubiquitin thiolesterase 14 antibody; Ubiquitin-specific-processing protease 14 antibody; UBP14_HUMAN antibody; USP 14 antibody; USP14 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C19 family. USP14/UBP6 subfamily.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions. Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.