USP14 Recombinant Rabbit Monoclonal Antibody [JU30-49] (ET1706-37)

UNIPROT #

P54578

PROTEIN NAME

USP14

SYNONYMS

Deubiquitinating enzyme 14 antibody;TGT antibody;tRNA guanine transglycosylase 60 kD subunit antibody;tRNA guanine transglycosylase antibody;Ubiquitin carboxyl terminal hydrolase 14 antibody;Ubiquitin carboxyl-terminal hydrolase 14 antibody;Ubiquitin specific peptidase 14 antibody;Ubiquitin specific processing protease 14 antibody;Ubiquitin specific protease 14 antibody;Ubiquitin thiolesterase 14 antibody;Ubiquitin-specific-processing protease 14 antibody;UBP14_HUMAN antibody;USP 14 antibody;USP14 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C19 family. USP14/UBP6 subfamily.

SUBCELLULAR LOCATION

Cytoplasm. Cell membrane.

FUNCTION

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP14 (ubiquitin specific peptidase 14), also known as TGT (tRNA-guanine transglycosylase), is a cytoplasmic protein that belongs to the ubiquitin-specific processing family of deubiquitinating enzymes. Existing as a homodimer within the cell, USP14 functions to cleave ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. In mice, defects or mutations in the gene encoding USP14 cause retarded growth or fetal death, indicating that USP14 plays a key role in early developmental processes. Multiple isoforms of USP14 are expressed due to alternative splicing events.