Urokinase Recombinant Rabbit Monoclonal Antibody [JM106-09] (ET1703-26)
Catalog# ET1703-26
Rabbit Monoclonal to Urokinase
-
WB
-
IHC-P
-
Human
-
Mouse
-
Rat
Positive control:
Lane 1: PC-3 cell lysate
Lane 2: MCF-7 cell lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Urokinase Recombinant Rabbit Monoclonal Antibody [JM106-09] (ET1703-26)
Immunogen
Synthetic peptide within human urokinase aa 50-99 / 431.
Host
Rabbit
Positive Control
PC-3 cell lysate, MCF-7 cell lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue, mouse lung tissue, rat lung tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM106-09
RRID
APPLICATION DILUTION
-
WB
-
1:500-1:2,000
-
IHC-P
-
1:5,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 49 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Urokinase
SYNONYMS
ATF antibody;ATF uPA antibody;BDPLT5 antibody;Plasminogen activator antibody;Plasminogen activator urinary antibody;Plasminogen activator urokinase antibody;PLAU antibody;QPD antibody;u PA antibody;U plasminogen activator antibody;u-PA antibody;U-plasminogen activator antibody;uPA antibody;URK antibody;UROK_HUMAN antibody;Urokinase plasminogen activator antibody;Urokinase type plasminogen activator antibody;Urokinase type plasminogen activator precursor antibody;Urokinase-type plasminogen activator chain B antibody
SEQUENCE SIMILARITIES
Belongs to the peptidase S1 family.
TISSUE SPECIFICITY
Expressed in the prostate gland and prostate cancers.
POST-TRANSLATIONAL MODIFICATION
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. Urokinase was originally isolated from human urine, and it is also present in the blood and in the extracellular matrix of many tissues. The primary physiological substrate of this enzyme is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolytic cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This cascade had been involved in vascular diseases and cancer progression.
