UQCRH Recombinant Rabbit Monoclonal Antibody [JE62-25] (HA720113)

UNIPROT #

P07919

PROTEIN NAME

UQCRH

SYNONYMS

Complex III subunit 6 antibody;Complex III subunit VIII antibody;Cytochrome b c1 complex subunit 6 antibody;Cytochrome b c1 complex subunit 6 mitochondrial antibody;Cytochrome c1 non heme 11 kDa protein antibody;High protein , mitochondrial antibody;MGC111572 antibody;Mitochondrial hinge protein antibody;QCR 6 antibody;QCR6 antibody;Ubiquinol cytochrome c reductase complex 11 kDa protein antibody;Ubiquinol cytochrome c reductase complex 11 kDa protein mitochondrial antibody;Ubiquinol cytochrome c reductase complex III subunit VIII antibody;Ubiquinol cytochrome c reductase hinge protein antibody;ubiquinol-cytochrome c reductase hinge protein antibody;UQCR8 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.