uPA Receptor Mouse Monoclonal Antibody [A6E8] (HA601039)

UNIPROT #

Q03405

PROTEIN NAME

uPA Receptor

SYNONYMS

CD 87 antibody;CD87 antibody;CD87 antigen antibody;MO 3 antibody;MO3 antibody;Monocyte activation antigen Mo3 antibody;Plasminogen activator receptor urokinase antibody;Plasminogen activator urokinase receptor antibody;PLAUR antibody;U PAR antibody;u plasminogen activator receptor antibody;U-PAR antibody;u-plasminogen activator receptor form 2 antibody;UPA receptor antibody;uPAR antibody;UPAR_HUMAN antibody;Urinary plasminogen activator receptor antibody;URKR antibody;Urokinase plasminogen activator receptor antibody;Urokinase plasminogen activator surface receptor antibody;urokinase-type plasminogen activator (uPA) receptor antibody

SUBCELLULAR LOCATION

Cell membrane, invadopodium membrane; Secreted.

FUNCTION

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.