Axl Mouse Monoclonal Antibody [C4-A8] (M1310-5)

UNIPROT #

P30530

PROTEIN NAME

UFO

SYNONYMS

Adhesion related kinase antibody;AI323647 antibody;Ark antibody;Axl antibody;AXL oncogene antibody;AXL receptor tyrosine kinase antibody;AXL transforming gene antibody;AXL transforming sequence/gene antibody;EC 2.7.10.1 antibody;JTK11 antibody;Oncogene AXL antibody;Tyro7 antibody;Tyrosine protein kinase receptor UFO antibody;Tyrosine-protein kinase receptor UFO antibody;UFO antibody;UFO_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

TISSUE SPECIFICITY

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.; Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. AXL receptor tyrosine kinase has been shown to interact with TENC1.Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.