Lane 1: mouse kidney tissue lysate
Lane 2: mouse liver tissue lysate
Recombinant Rabbit monoclonal primary
Ubiquitin-like modifier-activating enzyme 1 Recombinant Rabbit Monoclonal Antibody [SD08-62] (ET1612-82)
Mouse kidney tissue lysate, mouse liver tissue lysate, Hela, SKOV-3, A549, mouse ovary tissue, human kidney tissue, K562.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Ubiquitin-like modifier-activating enzyme 1
A1S9 antibody; A1S9 protein antibody; A1S9T and BN75 temperature sensitivity complementing antibody; A1S9T antibody; A1ST antibody; AMCX1 antibody; CFAP124 antibody; CTD-2522E6.1 antibody; GXP 1 antibody; GXP1 antibody; MGC4781 antibody; POC20 antibody; POC20 centriolar protein homolog antibody; Protein A1S9 antibody; SMAX2 antibody; Uba1 antibody; UBA1, ubiquitin-activating enzyme E1 homolog A antibody; UBA1_HUMAN antibody; UBA1A antibody; UBE 1 antibody; UBE 1X antibody; UBE1 antibody; UBE1X antibody; Ubiquitin activating enzyme E1 antibody; Ubiquitin-activating enzyme E1 antibody; Ubiquitin-like modifier-activating enzyme 1 antibody
Belongs to the ubiquitin-activating E1 family.
Detected in erythrocytes (at protein level). Ubiquitous.
Nucleus, Mitochondrion, Cytoplasm.
The ubiquitin activating enzyme E1 (UBE1) catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Specifically, UBE1 functions to adenylate the C-terminal glycine residue of ubiquitin, a reaction that is ATP-dependent and is proceeded by the formation of a thiolester bond with a cysteine residue of UBE1. The UBE1-activated ubiquitin is then transferred to a ubiquitin conjugated enzyme, which donates the ubiquitin residue to target substrates. The UBE1 gene is an example of an X-Y homologous gene, which is X-linked with a distinct Y-linked gene in many mammals. However, no UBE1 homolog is detectable on the human Y chromosome. UBE1 is thought to escape X inactivation in humans.