UBE2T Recombinant Rabbit Monoclonal Antibody [JE65-79] (HA721385)

UNIPROT #

Q9NPD8

PROTEIN NAME

UBE2T

SYNONYMS

Cell proliferation inducing gene 50 protein antibody;Cell proliferation-inducing gene 50 protein antibody;HSPC150 antibody;HSPC150 protein similar to ubiquitin conjugating enzyme antibody;PIG50 antibody;Ube2t antibody;UBE2T_HUMAN antibody;Ubiquitin carrier protein T antibody;Ubiquitin conjugating enzyme antibody;ubiquitin conjugating enzyme E2 T antibody;Ubiquitin conjugating enzyme E2T antibody;Ubiquitin protein ligase T antibody;Ubiquitin-conjugating enzyme E2 T antibody;Ubiquitin-protein ligase T antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.