UBE2C Recombinant Rabbit Monoclonal Antibody [JE38-67] (HA722454)

UNIPROT #

O00762

PROTEIN NAME

UBE2C

SYNONYMS

Cyclin selective ubiquitin carrier protein antibody;dJ447F3.2 antibody;Mitotic specific ubiquitin conjugating enzyme antibody;UB E2C antibody;UBCH 10 antibody;UbcH10 antibody;UBE 2C antibody;Ube2c antibody;UBE2C_HUMAN antibody;Ubiquitin carrier protein C antibody;Ubiquitin carrier protein E2 C antibody;Ubiquitin carrier protein E2C antibody;Ubiquitin conjugating enzyme E2 C antibody;Ubiquitin conjugating enzyme E2C antibody;Ubiquitin protein ligase C antibody;Ubiquitin-conjugating enzyme E2 C antibody;Ubiquitin-protein ligase C antibody

SUBCELLULAR LOCATION

Cytosol. Nucleoplasm.Nucleus.

FUNCTION

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2.