UBE1C Rabbit Polyclonal Antibody (R1706-14)

UNIPROT #

Q8TBC4

PROTEIN NAME

UBE1C

SYNONYMS

DKFZp566J164 antibody;EC 6.3.2. antibody;hUba3 antibody;MGC22384 antibody;NEDD8 activating enzyme E1 catalytic subunit antibody;NEDD8 activating enzyme E1C antibody;Nedd8 activating enzyme hUba3 antibody;NEDD8-activating enzyme E1 catalytic subunit antibody;NEDD8-activating enzyme E1C antibody;uba3 antibody;UBA3 ubiquitin activating enzyme E1 homolog antibody;UBA3_HUMAN antibody;UBE1C antibody;Ubiquitin activating enzyme 3 antibody;Ubiquitin activating enzyme E1C antibody;Ubiquitin-activating enzyme 3 antibody;Ubiquitin-activating enzyme E1C antibody;Ubiquitin-like modifier-activating enzyme 3 antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Ubiquitin is an abundant, highly conserved protein found in all eukaryotic cells either free or covalently attached to cellular proteins. The primary function of ubiquitin in mammalian systems is to clear abnormal, foreign and improperly folded proteins by targeting them for proteosome degradation. UBA3 (ubiquitin-like modifier activating enzyme 3), also known as NEDD8-activating enzyme E1 catalytic subunit or UBE1C (ubiquitin-activating enzyme E1C), is a 463 amino acid protein belonging to the ubiquitin-activating E1 family and UBA3 subfamily. Ubiquitously expressed, UBA3 acts as an activator to NEDD8, a ubiquitin-like protein, thus regulating cell division, signaling and embryogenesis. UBA3 exists as two isoforms due to alternative splicing events.