UBA3 Mouse Monoclonal Antibody [1B6-6-5] (EM1901-64)

UNIPROT #

Q8TBC4

PROTEIN NAME

UBA3

SYNONYMS

DKFZp566J164 antibody;EC 6.3.2. antibody;hUba3 antibody;MGC22384 antibody;NEDD8 activating enzyme E1 catalytic subunit antibody;NEDD8 activating enzyme E1C antibody;Nedd8 activating enzyme hUba3 antibody;NEDD8-activating enzyme E1 catalytic subunit antibody;NEDD8-activating enzyme E1C antibody;uba3 antibody;UBA3 ubiquitin activating enzyme E1 homolog antibody;UBA3_HUMAN antibody;UBE1C antibody;Ubiquitin activating enzyme 3 antibody;Ubiquitin activating enzyme E1C antibody;Ubiquitin-activating enzyme 3 antibody;Ubiquitin-activating enzyme E1C antibody;Ubiquitin-like modifier-activating enzyme 3 antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Cytoplasm, cytosol, nucleus.

FUNCTION

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.