UAP56 Rabbit Polyclonal Antibody (HA500102)

UNIPROT #

Q13838

PROTEIN NAME

UAP56

SYNONYMS

0610030D10Rik antibody;4F2-LC6 antibody;56 kDa U2AF65-associated protein antibody;AI428441 antibody;ATP-dependent RNA helicase p47 antibody;B(0,+)-type amino acid transporter 1 antibody;BAT1 antibody;Bat1a antibody;D17H6S81E antibody;D17H6S81E-1 antibody;D6S81E antibody;D6S81Eh antibody;DDX39B antibody;DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B antibody;DEAD box protein UAP56 antibody;DX39B_HUMAN antibody;EC 3.6.1.- antibody;Glycoprotein-associated amino acid transporter b0,+AT1 antibody;HLA-B-associated transcript 1 protein antibody;HLA-B-associated transcript 1A antibody;HLA-B-associated transcript-1 antibody;MGC127051 antibody;MGC19235 antibody;MGC38799 antibody;nuclear RNA helicase (DEAD family) antibody;OTTHUMP00000029229 antibody;OTTHUMP00000165889 antibody;OTTHUMP00000165890 antibody;p47 antibody;Solute carrier family 7 member 9 antibody;Spliceosome RNA helicase BAT1 antibody;Spliceosome RNA helicase DDX39B antibody;U2AF65-associayed protein, 56-KD antibody;UAP56 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Spliceosome.

FUNCTION

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.