Lane 1: Rat brain
Lane 2: K562
Lane 3: A431
Lane 4: Mouse kidney
Recombinant Rabbit monoclonal primary
U1A Recombinant Rabbit Monoclonal Antibody [JB33-48] (ET7107-98)
Recombinant protein corresponding to n-terminal human u1a.
Rat brain tissue lysate, K562, A431, mouse kidney tissue lysate, 293T, SH-SY-5Y, SiHa， human lung cancer tissue, mouse liver tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
fc19d01 antibody; Mud1 antibody; small nuclear ribonucleoprotein polypeptide A antibody; snRNP A antibody; snRNP protein A antibody; SNRPA antibody; SNRPA_HUMAN antibody; U1 small nuclear ribonucleoprotein A antibody; U1 small nuclear RNP specific A antibody; U1 snRNP A antibody; U1 snRNP specific protein A antibody; U1-A antibody; U1A antibody; wu:fc19d01 antibody; zgc:77810 antibody
Belongs to the RRM U1 A/B'' family.
SNRPA (small nuclear ribonucleoprotein polypeptide A), also known as U1A (U1 snRNP protein A), is a component of the RNA spliceosome, a complex of proteins that are required for the precise excision of introns from pre-messenger RNA (pre-mRNA). Localizing to the nucleus, SNRPA contains two RRM (RNA recognition motif) domains, namely RRM1 and RRM2, and RRM1 specifically associates with the stem loop II of U1 snRNA (small nuclear RNA). In addition to functioning as a component of the U1 snRNP, SNRPA negatively regulates polyadenylation of SNRPA pre-mRNA, thereby negatively regulating itself. By inhibiting the addition of a polyA tail that would allow the pre-mRNA to mature, SNRPA causes the nuclear exosome degradation of the SNRPA pre-mRNA. At least 16% of cellular SNRPA also functions in an snRNP-free form (SF-A) that complexes with a group of non-snRNP proteins.