UNIPROT #

P29597

PROTEIN NAME

Tyk2

SYNONYMS

JTK 1 antibody; JTK1 antibody; Non receptor tyrosine protein kinase 2 antibody; Non receptor tyrosine protein kinase TYK2 antibody; Non-receptor tyrosine-protein kinase TYK2 antibody; OTTHUMP00000232745 antibody; OTTHUMP00000232746 antibody; OTTHUMP00000232748 antibody; Protein Tyrosine Kinase 2 antibody; TYK 2 antibody; Tyk2 antibody; TYK2_HUMAN antibody; Tyrosine kinase 2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

TISSUE SPECIFICITY

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.

SUBCELLULAR LOCATION

Cytoskeleton. Nucleus. Cytosol. Plasma membrane.

FUNCTION

TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.