Lane 1: PC-12 cell lysate
Lane 2: human skeletal muscle tissue lysate
Lane 3: NIH/3T3 cell lysate
Lane 4: Hela cell lysate
Recombinant Rabbit monoclonal primary
TXNIP Recombinant Rabbit Monoclonal Antibody [JM60-35] (ET1705-72)
PC-12 cell lysate, human skeletal muscle tissue lysate, NIH/3T3 cell lysate, Hela cell lysate, Hela, NIH/3T3, SH-SY5Y, human kidney tissue, human stomach carcinoma tissue, mouse kidney tissue, mouse stomach tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
EST01027 antibody; HHCPA78 antibody; THIF antibody; Thioredoxin binding protein 2 antibody; Thioredoxin interacting protein antibody; Thioredoxin-binding protein 2 antibody; Thioredoxin-interacting protein antibody; TXNIP antibody; TXNIP_HUMAN antibody; Upregulated by 1,25 dihydroxyvitamin D 3 antibody; VDUP1 antibody; Vitamin D3 up-regulated protein 1 antibody
Belongs to the arrestin family.
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.