Tryptophanyl tRNA synthetase / WRS Recombinant Rabbit Monoclonal Antibody [JE48-08] (ET7109-73)

UNIPROT #

P23381

PROTEIN NAME

Tryptophanyl tRNA synthetase / WRS

SYNONYMS

Gamma 2 antibody;GAMMA-2 antibody;Gamma2 antibody;hWRS antibody;IFI 53 antibody;IFI53 antibody;IFP 53 antibody;IFP53 antibody;Interferon induced protein 53 antibody;Interferon-induced protein 53 antibody;SYWC_HUMAN antibody;T2-TrpRS antibody;TrpRS antibody;Tryptophan tRNA ligase, cytoplasmic antibody;Tryptophan tRNA ligase 1 cytoplasmic antibody;Tryptophan tRNA ligase antibody;Tryptophan--tRNA ligase antibody;Tryptophanyl tRNA synthetase antibody;Tryptophanyl tRNA synthetase cytoplasmic antibody;WARS antibody;WARS protein antibody;WRS antibody

SEQUENCE SIMILARITIES

Belongs to the class-I aminoacyl-tRNA synthetase family.

POST-TRANSLATIONAL MODIFICATION

Proteolytic cleavage generates 2 forms; T1-TrpRS and T2-TrpRS.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.