TRPM4 Rabbit Polyclonal Antibody (ER1902-81)

UNIPROT #

Q8TD43

PROTEIN NAME

TRPM4

SYNONYMS

1110030C19Rik antibody;AW047689 antibody;Calcium-activated non-selective cation channel 1 antibody;FLJ20041 antibody;hTRPM4 antibody;Long transient receptor potential channel 4 antibody;LTrpC-4 antibody;LTrpC4 antibody;Melastatin 4 antibody;Melastatin like 2 protein antibody;Melastatin-4 antibody;Melastatin-like 2 antibody;Mls2s antibody;PFHB1B antibody;Transient receptor potential cation channel subfamily M member 4 antibody;Transient receptor potential cation channel, subfamily M, member 4 antibody;Trpm4 antibody;TRPM4_HUMAN antibody;TRPM4B antibody

SEQUENCE SIMILARITIES

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily.

TISSUE SPECIFICITY

Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. Expressed in keratocytes.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by PKC leads to increase the sensitivity to Ca(2+).; Sumoylated. Desumoylated by SENP1.

SUBCELLULAR LOCATION

Cell membrane, endoplasmic reticulum, golgi apparatus.

FUNCTION

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium.