Recombinant Rabbit monoclonal primary
Tropomyosin 1 Recombinant Rabbit Monoclonal Antibody [JG38-66] (ET7108-74)
Recombinant protein within human tropomyosin 1 aa 100-300.
Rat heart tissue, rat smooth muscle tissue, human heart tissue, mouse skeletal muscle tissue, MCF-7.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AA986836 antibody; AI854628 antibody; Alpha tropomyosin antibody; alpha-TM antibody; Alpha-tropomyosin antibody; C15orf13 antibody; cardiomyopathy, hypertrophic 3 antibody; CMD1Y antibody; CMH3 antibody; HTM alpha antibody; HTM-alpha antibody; OTTHUMP00000163688 antibody; sarcomeric tropomyosin kappa antibody; TM2 antibody; Tmpa antibody; TMSA antibody; Tpm-1 antibody; TPM1 antibody; TPM1_HUMAN antibody; tropomyosin 1 (alpha) antibody; tropomyosin 1 (alpha) isoform 1 antibody; tropomyosin 1 (alpha) isoform 2 antibody; tropomyosin 1 (alpha) isoform 3 antibody; tropomyosin 1 (alpha) isoform 4 antibody; tropomyosin 1 (alpha) isoform 5 antibody; tropomyosin 1 (alpha) isoform 6 antibody; tropomyosin 1 (alpha) isoform 7 antibody; Tropomyosin 1 antibody; Tropomyosin alpha 1 chain antibody; Tropomyosin alpha-1 chain antibody; Tropomyosin, skeletal muscle alpha antibody; Tropomyosin-1 antibody
Belongs to the tropomyosin family.
Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind Actin filaments and function to modulate Actin-Myosin interaction and stabilize Actin filament structure. Tropomyosin α is encoded by the TPM1 gene, which maps to human chromosome 15q22.1 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin β is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with Actin filaments may increase the rigidity of Actin filaments. Tropomyosin also interacts with Caldesmon to regulate smooth muscle contraction.