TROP2 Rabbit Polyclonal Antibody (ER1802-60)

UNIPROT #

P09758

PROTEIN NAME

TROP2

SYNONYMS

Cell surface glycoprotein Trop 2 antibody;Cell surface glycoprotein Trop-2 antibody;Cell surface glycoprotein Trop2 antibody;Epithelial glycoprotein 1 antibody;GA733 1 antibody;GA7331 antibody;M1S 1 antibody;M1S1 antibody;Membrane component chromosome 1 surface marker 1 antibody;Pancreatic carcinoma marker protein GA733 1 antibody;Pancreatic carcinoma marker protein GA733-1 antibody;Pancreatic carcinoma marker protein GA7331 antibody;TACD 2 antibody;TACD2_HUMAN antibody;TACSTD 2 antibody;Tacstd2 antibody;Trop 2 antibody;Trop2 antibody;Tumor associated calcium signal transducer 2 precursor antibody;Tumor-associated calcium signal transducer 2 antibody

SEQUENCE SIMILARITIES

Belongs to the EPCAM family.

TISSUE SPECIFICITY

Placenta, pancreatic carcinoma cell lines.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

TROP-2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP-2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment.